Evidence for increased immune mobilization in First Episode Psychosis compared with the prodromal stage in males

Karanikas, Evangelos, Griveas, Ioannis, Ntouros, Evangelos, Floros, Georgios and Garyfallos, George (2016) Evidence for increased immune mobilization in First Episode Psychosis compared with the prodromal stage in males. Psychiatry Research, 244 333-338. doi:10.1016/j.psychres.2016.07.059

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Author Karanikas, Evangelos
Griveas, Ioannis
Ntouros, Evangelos
Floros, Georgios
Garyfallos, George
Title Evidence for increased immune mobilization in First Episode Psychosis compared with the prodromal stage in males
Journal name Psychiatry Research   Check publisher's open access policy
ISSN 1872-7123
0165-1781
Publication date 2016-10-30
Sub-type Article (original research)
DOI 10.1016/j.psychres.2016.07.059
Open Access Status File (Author Post-print)
Volume 244
Start page 333
End page 338
Total pages 6
Place of publication E Park, Shannon, Clare Ireland
Publisher Elsevier Ireland
Language eng
Abstract The aim of the study was to gauge both the immune and neuroendocrine function in Ultra High Risk for psychosis (UHR) subjects and compare them with a cohort presenting with First Episode Psychosis (FEP). We recruited two groups, the first group consisted of 12 UHR males and the second of 25 males with FEP. We measured serum cortisol levels at 08:00, 12:00, 18:00 with their Area Under Curve with respect to the ground (AUCg) and the increase (AUCi) and we measured serum cytokines levels, Interleukin-1a, IL-1a, IL-2, IL-4,IL-5,IL-6,IL-8, IL-10,IL-12, IL-17a, Tumor Necrosis Factor-a (TNF-a), Interferon-γ (IFN-γ). Dexamethasone Suppression Test (DST) was also performed. The results suggest higher levels of both pro-inflammatory (TNF-a, IL-2, IL-12, IFN-γ) and anti-inflammatory (IL-10) cytokines in the FEP group compared with the UHR counterparts. Regarding the HPA axis function, the prodromal subjects showed a trend for higher AUCg and AUCi change/decrease cortisol levels. On the contrary, the DST results did not differ between the groups. No significant associations were demonstrated within each group among cytokines, cortisol and psychopathology. The findings favor a hypothesis of a relatively increased mobilization of both the pro- and anti-inflammatory cytokine networks, in FEP compared with that of UHR subjects.
Keyword Cortisol
Cytokines
First Episode Psychosis
HPA axis
Immunity
Inflammation
Ultra high risk
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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