Pulse size distributions in tunable resistive pulse sensing

Weatherall, Eva, Hauer, Peter, Vogel, Robert and Willmott, Geoff R. (2016) Pulse size distributions in tunable resistive pulse sensing. Analytical Chemistry, 88 17: 8648-8656. doi:10.1021/acs.analchem.6b01818

Author Weatherall, Eva
Hauer, Peter
Vogel, Robert
Willmott, Geoff R.
Title Pulse size distributions in tunable resistive pulse sensing
Journal name Analytical Chemistry   Check publisher's open access policy
ISSN 1520-6882
Publication date 2016-09-06
Sub-type Article (original research)
DOI 10.1021/acs.analchem.6b01818
Open Access Status Not yet assessed
Volume 88
Issue 17
Start page 8648
End page 8656
Total pages 9
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Abstract The use of resistive pulse sensors for submicron particle size measurements relies on a clear understanding of pulse size distributions. Here, broadening of such distributions has been studied and explained using conical pores and nominally monodisperse polystyrene particles 200-800 nm in diameter. The use of tunable resistive pulse sensing (TRPS) enabled continuous in situ control of the pore size during experiments. Pulse size distributions became broader when the pore size was increased and featured two distinct peaks. Similar distributions were generated using finite element simulations, which suggested that relatively large pulses are produced by particles with trajectories passing near to the edge of the pore. Other experiments determined that pulse size distributions are independent of applied voltage but broaden with increasing pressure applied across the membrane. The applied pressure could also be reversed in response to a pulse, which enabled repeated measurement of individual particles moving back and forth through the pore. Hydrodynamic and electrophoretic focusing each appear to affect particle trajectories under certain conditions.
Keyword Analytical Chemistry
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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