The evolution of the molecular response to stress and its relevance to trauma and stressor-related disorders

Watson, Ian P. Burges, Bruene, Martin and Bradley, Adrian J. (2016) The evolution of the molecular response to stress and its relevance to trauma and stressor-related disorders. Neuroscience and Biobehavioral Reviews, 68 134-147. doi:10.1016/j.neubiorev.2016.05.010


Author Watson, Ian P. Burges
Bruene, Martin
Bradley, Adrian J.
Title The evolution of the molecular response to stress and its relevance to trauma and stressor-related disorders
Journal name Neuroscience and Biobehavioral Reviews   Check publisher's open access policy
ISSN 1873-7528
0149-7634
Publication date 2016-09-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.neubiorev.2016.05.010
Open Access Status Not yet assessed
Volume 68
Start page 134
End page 147
Total pages 14
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 3206 Neuropsychology and Physiological Psychology
2805 Cognitive Neuroscience
2802 Behavioral Neuroscience
Abstract The experience of "stress", in its broadest meaning, is an inevitable part of life. All living creatures have evolved multiple mechanisms to deal with such threats and challenges and to avoid damage to the organism that may be incurred from these stress responses. Trauma and stressor-related disorders are psychiatric conditions that are caused specifically by the experience of stress, though depression, anxiety and some other disorders may also be unleashed by stress. Stress, however, is not a mandatory criterion of these diagnoses. This article focuses on the evolution of the neurochemicals involved in the response to stress and the systems in which they function. This includes the skin and gut, and the immune system.Evidence suggests that responses to stress are evolutionarily highly conserved, have wider involvement than the hypothalamic pituitary adrenal stress axis alone, and that excessive stress responses can produce stressor-related disorders in both humans and animals.
Keyword Immunology and stress physiology
Molecular evolution
Skin and gut responses to stress
Stress and stressor-related disorders
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
 
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