The impact of chemotherapy on complications associated with mastectomy and immediate autologous tissue reconstruction

Tanaka, Shoichiro, Hayek, Genevieve, Jayapratap, Pravitha, Yerrasetti, Sita, Hilaire, Hugo St., Sadeghi, Ali, Corsetti, Ralph and Fuhrman, George (2016) The impact of chemotherapy on complications associated with mastectomy and immediate autologous tissue reconstruction. American Surgeon, 82 8: 713-717.

Author Tanaka, Shoichiro
Hayek, Genevieve
Jayapratap, Pravitha
Yerrasetti, Sita
Hilaire, Hugo St.
Sadeghi, Ali
Corsetti, Ralph
Fuhrman, George
Title The impact of chemotherapy on complications associated with mastectomy and immediate autologous tissue reconstruction
Journal name American Surgeon   Check publisher's open access policy
ISSN 0003-1348
1555-9823
Publication date 2016-08-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 82
Issue 8
Start page 713
End page 717
Total pages 5
Place of publication Cumming, GA, United States
Publisher Southeastern Surgical Congress
Collection year 2017
Language eng
Formatted abstract
We performed this study to evaluate the impact of chemotherapy on the outcomes associated with immediate autologous tissue reconstruction (IATR) in the treatment of breast cancer. Patients were divided into two groups: Group 1 received chemotherapy before surgery and Group 2 did not receive chemotherapy. Records were reviewed to identify demographics, comorbidities, histology, and wound healing complications. Groups were compared using Kruskal-Wallis and Fisher exact tests as appropriate. A total of 128 patients were identified: 29 received chemotherapy before surgery (Group 1) and 99 did not receive chemotherapy (Group 2). Group 1 patients were more likely to have diabetes 27 per cent versus 6 per cent (P = 0.005) despite both groups having a mean body mass index of 30. Group 2 patients had less advanced stage disease as expected because they did not receive chemotherapy; 37 per cent of Group 2 patients had stage 0 breast cancer (P < 0.001). The incidence of wound complications was 17 per cent in Group 1 and 12 per cent in Group 2 (P = NS). Preoperative chemotherapy for breast cancer followed by IATR was associated with no increased risk of healing complications. IATR can be offered to patients who require preoperative chemotherapy, and their healing will not be impaired as a result of the chemotherapy.
Keyword Surgical adjuvant breast
Comparing total mastectomy
Receptor-positive tumors
Project protocol B-27
Nsabp clinical-trial
Neoadjuvant chemotherapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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