Caotivating new roles of F-actin cortex in exocytosis and bulk endocytosis in neurosecretory cells

Meunier, Frederic A. and Gutierrez, Luis M. (2016) Caotivating new roles of F-actin cortex in exocytosis and bulk endocytosis in neurosecretory cells. Trends in Neurosciences, 39 9: 605-613. doi:10.1016/j.tins.2016.07.003


Author Meunier, Frederic A.
Gutierrez, Luis M.
Title Caotivating new roles of F-actin cortex in exocytosis and bulk endocytosis in neurosecretory cells
Journal name Trends in Neurosciences   Check publisher's open access policy
ISSN 0166-2236
1878-108X
Publication date 2016-09-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tins.2016.07.003
Open Access Status Not yet assessed
Volume 39
Issue 9
Start page 605
End page 613
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract The cortical actin network is a tight array of filaments located beneath the plasma membrane. In neurosecretory cells, secretory vesicles are recruited on this network via a small insert isoform of myosin VI in a Ca(2+)-dependent manner. Upon secretagogue stimulation, myosin II mediates a relaxation of the actin network leading to synchronous translocation of bound or caged vesicles to the plasma membrane where they undergo exocytosis. F-actin is also recruited to secretory sites, where structural changes are detected immediately preceding and following exocytic events. Here we examine the mechanism underpinning the astonishing multifunctionality of this network in the various stages of vesicular exocytosis and compensatory bulk endocytosis. We propose a theoretical framework incorporating critical roles of the actin network in coupling these processes.
Formatted abstract
The cortical actin network is a tight array of filaments located beneath the plasma membrane. In neurosecretory cells, secretory vesicles are recruited on this network via a small insert isoform of myosin VI in a Ca2+-dependent manner. Upon secretagogue stimulation, myosin II mediates a relaxation of the actin network leading to synchronous translocation of bound or caged vesicles to the plasma membrane where they undergo exocytosis. F-actin is also recruited to secretory sites, where structural changes are detected immediately preceding and following exocytic events. Here we examine the mechanism underpinning the astonishing multifunctionality of this network in the various stages of vesicular exocytosis and compensatory bulk endocytosis. We propose a theoretical framework incorporating critical roles of the actin network in coupling these processes.
Keyword Secretory vesicles
Cortical actin network
Myosin II
Myosin VI
Neurosecretory cells
Exocytosis–endocytosis coupling
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 09 Oct 2016, 10:24:15 EST by System User on behalf of Clem Jones Centre for Ageing Dementia Research