Emerging pathogenic links between microbiota and the gut-lung axis.

Budden, Kurtis F. , Gellatly, Shaan L. , Wood, David L., Cooper, Matthew A. , Morrison, Mark, Hugenholtz, Philip and Hansbro, Philip M. (2016) Emerging pathogenic links between microbiota and the gut-lung axis.. Nature Reviews Microbiology, 15 1: 55-63. doi:10.1038/nrmicro.2016.142

Author Budden, Kurtis F. 
Gellatly, Shaan L. 
Wood, David L.
Cooper, Matthew A. 
Morrison, Mark
Hugenholtz, Philip
Hansbro, Philip M.
Title Emerging pathogenic links between microbiota and the gut-lung axis.
Journal name Nature Reviews Microbiology   Check publisher's open access policy
ISSN 1740-1526
Publication date 2016-10-03
Year available 2017
Sub-type Article (original research)
DOI 10.1038/nrmicro.2016.142
Open Access Status Not yet assessed
Volume 15
Issue 1
Start page 55
End page 63
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2400 Immunology and Microbiology
Abstract The microbiota is vital for the development of the immune system and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut have recently been linked to alterations in immune responses and to disease development in the lungs. In this Opinion article, we review the microbial species that are usually found in healthy gastrointestinal and respiratory tracts, their dysbiosis in disease and interactions with the gut–lung axis. Although the gut–lung axis is only beginning to be understood, emerging evidence indicates that there is potential for manipulation of the gut microbiota in the treatment of lung diseases.
Keyword Asthma
Bacterial host response
Respiratory tract diseases
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 9841 3626187
Institutional Status UQ

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Created: Fri, 07 Oct 2016, 19:55:40 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences