Human gingival Langerhans cells in health and disease

Newcomb G.M. and Powell R.N. (1986) Human gingival Langerhans cells in health and disease. Journal of Periodontal Research, 21 6: 640-652. doi:10.1111/j.1600-0765.1986.tb01501.x


Author Newcomb G.M.
Powell R.N.
Title Human gingival Langerhans cells in health and disease
Journal name Journal of Periodontal Research   Check publisher's open access policy
ISSN 1600-0765
Publication date 1986-01-01
Sub-type Article (original research)
DOI 10.1111/j.1600-0765.1986.tb01501.x
Volume 21
Issue 6
Start page 640
End page 652
Total pages 13
Subject 3506 Periodontics
Abstract Epithelial Langerhans cells in samples of healthy and diseased gingival tissue were studied using ATPase histochemistry and the monoclonal antibodies OKT6 and anti HLA‐DR. In healthy gingiva Langerhans cells were seen in both oral and sulcular epithelium; they were generally positioned in the basal layers. No Langerhans cells were seen in junctional epithelium. In diseased tissue there was a large increase in the number of Langerhans cells in both oral and sulcular epithelium with many more being situated in the stratum spinosum. There was an increase in the expression of the Class 2 antigen, HLA‐DR, and morphological polarization occurred with dendrites preferentially orientated towards the surface. No Langerhans cells were seen in the pocket lining epithelium of periodontally diseased gingiva. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 04 Oct 2016, 12:56:18 EST by System User