Preimplantation development in the streptozotocin-induced diabetic mouse

Beebe L.F.S. and Kaye P.L. (1990) Preimplantation development in the streptozotocin-induced diabetic mouse. Reproduction, Fertility and Development, 2 4: 407-412. doi:10.1071/RD9900407

Author Beebe L.F.S.
Kaye P.L.
Title Preimplantation development in the streptozotocin-induced diabetic mouse
Journal name Reproduction, Fertility and Development   Check publisher's open access policy
ISSN 1448-5990
Publication date 1990-01-01
Sub-type Article (original research)
DOI 10.1071/RD9900407
Volume 2
Issue 4
Start page 407
End page 412
Total pages 6
Language eng
Subject 1103 Clinical Sciences
1309 Developmental Biology
1311 Genetics
1305 Biotechnology
1312 Molecular Biology
1310 Endocrinology
2743 Reproductive Medicine
Abstract Streptozotocin (STZ) was used to develop a diabetic mouse model in which to study the development of the preimplantation embryo. STZ doses of 0, 160, 190, 210 and 240 mg kg-1 were given; 190 mg kg-1 was found to be the most suitable as the standard diabetogenic dose, providing about 60% mice with plasma glucose >20 mM. The STZ-diabetic mice responded to superovulation with 10 i.u. of gonadotrophin in the same manner as control mice, producing similar embryo numbers at 48 h, 72 h and 96 h post-hCG. Furthermore, the proportion of 2-cell embryos collected from STZ-diabetic mice which developed to blastocysts in vitro was similar to that of 2-cell embryos from control mice. The STZ-diabetic mouse model after superovulation thus produced normal early preimplantation embryos whose development can be examined in detail in a diabetic environment.
Keyword Diabetes
Preimplantation embryo
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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