Modulation by dopamine antagonists of DNA synthesis in the pituitary gland of the male rat

Jacobi J.M. and Lloyd H.M. (1981) Modulation by dopamine antagonists of DNA synthesis in the pituitary gland of the male rat. Neuroendocrinology, 33 2: 97-100. doi:10.1159/000123210


Author Jacobi J.M.
Lloyd H.M.
Title Modulation by dopamine antagonists of DNA synthesis in the pituitary gland of the male rat
Journal name Neuroendocrinology   Check publisher's open access policy
ISSN 1423-0194
Publication date 1981-01-01
Sub-type Article (original research)
DOI 10.1159/000123210
Open Access Status Not yet assessed
Volume 33
Issue 2
Start page 97
End page 100
Total pages 4
Subject 1310 Endocrinology
2712 Endocrinology, Diabetes and Metabolism
2804 Cellular and Molecular Neuroscience
2807 Endocrine and Autonomic Systems
2800 Neuroscience
Abstract Pituitary DNA synthesis and serum and pituitary concentrations of prolactin were measured in male rats given the dopamine antagonist haloperidol or pimozide, and the dopamine agonist bromocriptine. Increased DNA synthesis was observed 24 h after a single in jection of haloperidol and on each day of the 5-day period of pimozide administration. Haloperidol and pimozide increased serum prolactin levels. Pituitary prolactin concentrations fell 12 h after haloperidol. recovering by 24 h, and 24 and 48 h after pimozide, recovering by 72 h. Bromocriptine lowered pituitary DNA synthesis and serum prolactin levels and induced a transient rise in pituitary prolactin concentrations. The results indicate that dopamine agonists and antagonists modulate DNA synthesis in the pituitary gland of the rat.
Keyword Anterior pituitary gland
Bromocriptine
DNA synthesis
Haloperidol
Pimozide
Prolactin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 04 Oct 2016, 11:58:24 EST by System User