Escherichia coli contains a set of genes homologous to those involved in protein secretion, DNA uptake and the assembly of type-4 fimbriae in other bacteria

Whitchurch C.B. and Mattick J.S. (1994) Escherichia coli contains a set of genes homologous to those involved in protein secretion, DNA uptake and the assembly of type-4 fimbriae in other bacteria. Gene, 150 1: 9-15. doi:10.1016/0378-1119(94)90851-6


Author Whitchurch C.B.
Mattick J.S.
Title Escherichia coli contains a set of genes homologous to those involved in protein secretion, DNA uptake and the assembly of type-4 fimbriae in other bacteria
Journal name Gene   Check publisher's open access policy
ISSN 0378-1119
Publication date 1994-12-02
Sub-type Article (original research)
DOI 10.1016/0378-1119(94)90851-6
Open Access Status Not yet assessed
Volume 150
Issue 1
Start page 9
End page 15
Total pages 7
Subject 1311 Genetics
Abstract A specialised system involved in a diverse array of functions, including the biogenesis of fimbriae, protein secretion and DNA uptake, has recently been found to be widespread in the eubacteria. These systems have in common several sets of related genes, including those encoding proteins containing leader sequences homologous to that of the type-4 fimbrial subunit (prepilin), a prepilin-type leader peptidase, a cytoplasmic nucleotide-binding protein, and other proteins located in the inner and outer membranes [Hobbs, M. and Mattick, J.S., Mol Microbiol. 10 (1993) 233-243]. Here, we show that Escherichia coli contains at least nine homologs of this system, and present complete sequence data for five of the genes involved (ppdD, hopB, hopC, hopD and pshM), as well as for an adjacent gene (nadC), which encodes quinolic acid phosphoribosyltranferase. Insertional mutagenesis of hopB and hopD failed to reveal any obvious effects on cell viability, morphogenesis of M 13 phage, conjugative transfer of the F plasmid, or protein secretion.
Keyword DNA sequence
filamentous phage
NadC
pili
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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