The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma

Byrne J.A. and Smith P.J. (1993) The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma. Human Genetics, 91 3: 275-277. doi:10.1007/BF00218271


Author Byrne J.A.
Smith P.J.
Title The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma
Journal name Human Genetics   Check publisher's open access policy
ISSN 0340-6717
Publication date 1993-01-01
Sub-type Article (original research)
DOI 10.1007/BF00218271
Volume 91
Issue 3
Start page 275
End page 277
Total pages 3
Publisher Springer-Verlag
Subject 2716 Genetics (clinical)
1311 Genetics
Abstract We have utilized the polymerase chain reaction (PCR) to amplify a transcribed Taq1 polymorphism in the ribonucleotide reductase M1 subunit (RRM1) gene at chromosome 11p15.5, to investigate whether this locus is subjected to imprinting in embryonal tumours. The polymorphism was amplified from cDNA from 6 Wilms' tumours, one hepatoblastoma and corresponding samples of adjacent kidney or liver from individuals who were constitutionally heterozygous for the polymorphism. Taq1 digestion of PCR products revealed that both alleles were transcribed in all samples where both were present at the genomic level, indicating that the RRM1 locus is not subjected to imprinting in Wilms' tumour or hepatoblastoma.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 04 Oct 2016, 11:51:38 EST by System User