Concerning so‐called sexual dimorphism in acetazolamide‐induced dysmelia of rats

Vickers T.H. (1976) Concerning so‐called sexual dimorphism in acetazolamide‐induced dysmelia of rats. Teratology, 13 3: 305-307. doi:10.1002/tera.1420130310


Author Vickers T.H.
Title Concerning so‐called sexual dimorphism in acetazolamide‐induced dysmelia of rats
Journal name Teratology
ISSN 1096-9926
Publication date 1976-01-01
Sub-type Article (original research)
DOI 10.1002/tera.1420130310
Volume 13
Issue 3
Start page 305
End page 307
Total pages 3
Subject 2710 Embryology
3005 Toxicology
1309 Developmental Biology
2307 Health, Toxicology and Mutagenesis
Abstract Examination, including gonadal sexing, of Sprague‐Dawley‐derived rats with acetazolamide‐induced dysmelia did not reveal deformity in significantly more females than males. The attributes considered were frequency of defects, prevalence of bilateral lesions, number of litters in which both sexes were present but only 1 was malformed, and severity of anomalies as assessed by the number of residual digits in malformed paws. Unlike the morphological pattern of the dysmelia, which seems stereotyped among the sexes in mice and rats, sex‐determined variation in its severity is not a constant feature of the limb lesions induced by acetazolamide in rats. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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