Alcohol exposure impairs trophoblast survival and alters subtype-specific gene expression in vitro

Kalisch-Smith, J. I., Outhwaite, J. E., Simmons, D. G., Pantaleon, M. and Moritz, K. M. (2016) Alcohol exposure impairs trophoblast survival and alters subtype-specific gene expression in vitro. Placenta, 46 87-91. doi:10.1016/j.placenta.2016.08.080

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Author Kalisch-Smith, J. I.
Outhwaite, J. E.
Simmons, D. G.
Pantaleon, M.
Moritz, K. M.
Title Alcohol exposure impairs trophoblast survival and alters subtype-specific gene expression in vitro
Formatted title
Alcohol exposure impairs trophoblast survival and alters subtype-specific gene expression in vitro
Journal name Placenta   Check publisher's open access policy
ISSN 1532-3102
0143-4004
Publication date 2016-10-01
Year available 2016
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1016/j.placenta.2016.08.080
Open Access Status File (Author Post-print)
Volume 46
Start page 87
End page 91
Total pages 5
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Abstract Maternal alcohol consumption is common prior to pregnancy recognition and in the rat results in altered placental development and fetal growth restriction. To assess the effect of ethanol (EtOH) exposure on the differentiation of trophoblast stem (TS) cells, mouse TS lines were differentiated in vitro for 6 days in 0%, 0.2% or 1% EtOH. This reduced both trophoblast survival and expression of labyrinth and junctional zone trophoblast subtype-specific genes. This suggests that fetal growth restriction and altered placental development associated with maternal alcohol consumption in the periconceptional period could be mediated in part by direct effects on trophoblast development.
Formatted abstract
Maternal alcohol consumption is common prior to pregnancy recognition and in the rat results in altered placental development and fetal growth restriction. To assess the effect of ethanol (EtOH) exposure on the differentiation of trophoblast stem (TS) cells, mouse TS lines were differentiated in vitro for 6 days in 0%, 0.2% or 1% EtOH. This reduced both trophoblast survival and expression of labyrinth and junctional zone trophoblast subtype-specific genes. This suggests that fetal growth restriction and altered placental development associated with maternal alcohol consumption in the periconceptional period could be mediated in part by direct effects on trophoblast development.
Keyword Apoptosis
Differentiation
Ethanol
Placenta
Programming
Q-Index Code CX
Q-Index Status Provisional Code
Grant ID APP1046137
Institutional Status UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
 
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