Epithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinoma

Jayachandran, Aparna, Dhungel, Bijay and Steel, Jason C. (2016) Epithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinoma. Journal of Hematology and Oncology, 9 74: 698-706. doi:10.1186/s13045-016-0307-9

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ407138_OA.pdf Full text (open access) application/pdf 812.14KB 0

Author Jayachandran, Aparna
Dhungel, Bijay
Steel, Jason C.
Title Epithelial-to-mesenchymal plasticity of cancer stem cells: therapeutic targets in hepatocellular carcinoma
Journal name Journal of Hematology and Oncology   Check publisher's open access policy
ISSN 1756-8722
Publication date 2016-08-30
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/s13045-016-0307-9
Open Access Status File (Publisher version)
Volume 9
Issue 74
Start page 698
End page 706
Total pages 12
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Subject 2720 Hematology
1312 Molecular Biology
2730 Oncology
1306 Cancer Research
Abstract Hepatocellular carcinoma (HCC) remains one of the most common and lethal malignancies worldwide despite the development of various therapeutic strategies. A better understanding of the mechanisms responsible for HCC initiation and progression is essential for the development of more effective therapies. The cancer stem cell (CSC) model has provided new insights into the development and progression of HCC. CSCs are specialized tumor cells that are capable of self-renewal and have long-term repopulation potential. As they are important mediators of tumor proliferation, invasion, metastasis, therapy resistance, and cancer relapse, the selective targeting of this crucial population of cells has the potential to improve HCC patient outcomes and survival. In recent years, the role of epithelial-to-mesenchymal transition (EMT) in the advancement of HCC has gained increasing attention. This multi-step reprograming process resulting in a phenotype switch from an epithelial to a mesenchymal cellular state has been closely associated with the acquisition of stem cell-like attributes in tumors. Moreover, CSC mediates tumor metastasis by maintaining plasticity to transition between epithelial or mesenchymal states. Therefore, understanding the molecular mechanisms of the reprograming switches that determine the progression through EMT and generation of CSC is essential for developing clinically relevant drug targets. This review provides an overview of the proposed roles of CSC in HCC and discusses recent results supporting the emerging role of EMT in facilitating hepatic CSC plasticity. In particular, we discuss how these important new insights may facilitate rational development of combining CSC- and EMT-targeted therapies in the future.
Keyword Hepatocellular carcinoma
Cancer stem cells
Cancer-initiating cells
Epithelial-to-mesenchymal transition
Cellular plasticity
Tumor heterogeneity
Drug resistance
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 02 Oct 2016, 10:50:54 EST by System User on behalf of School of Medicine