Maternal exposure to perfluoroalkyl acids measured in whole blood and birth outcomes in offspring

Callan, A. C., Rotander, A., Thompson, K., Heyworth, J., Mueller, J. F., Odland, J. O. and Hinwood, A. L. (2016) Maternal exposure to perfluoroalkyl acids measured in whole blood and birth outcomes in offspring. Science of the Total Environment, 569-570 1107-1113. doi:10.1016/j.scitotenv.2016.06.177


Author Callan, A. C.
Rotander, A.
Thompson, K.
Heyworth, J.
Mueller, J. F.
Odland, J. O.
Hinwood, A. L.
Title Maternal exposure to perfluoroalkyl acids measured in whole blood and birth outcomes in offspring
Journal name Science of the Total Environment   Check publisher's open access policy
ISSN 0048-9697
1879-1026
Publication date 2016-11-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.scitotenv.2016.06.177
Open Access Status Not yet assessed
Volume 569-570
Start page 1107
End page 1113
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Subject 2305 Environmental Engineering
2304 Environmental Chemistry
2311 Waste Management and Disposal
2310 Pollution
Abstract Perfluoralkyl and polyfluoralkyl substances have been measured in plasma and serum of pregnant women as a measure of prenatal exposure. Increased concentrations of individual perfluoroalkyl acids (PFAAs), (typically perfluorooctanoic acid (PFOA) and perfluoroctane sulfonate (PFOS) have been reported to be associated with reductions in birth weight and other birth outcomes. We undertook a study of 14 PFAAs in whole blood (including PFOS, PFHxS, PFHpA, PFOA, PFNA, PFDA and PFUnDA) from 98 pregnant women in Western Australia from 2008 to 2011. Median concentrations (in μg/L) were: PFOS 1.99; PFHxS 0.33; PFOA 0.86; PFNA 0.30; PFDA 0.12 and PFUnDA 0.08. Infants born to women with the highest tertile of PFHxS exposure had an increased odds of being b95% of their optimal birth weight (OR 3.5, 95% CI 1.1 11.5). Conversely, maternal blood concentrations of PFUnDA were associated with non-significant increases in average birth weight (+102 g, 95% CI −41, 245) and significant increases in proportion of optimal birth weight (+4.7%, 95% CI 0.7, 8.8) per ln-unit change. This study has reported a range of PFAAs in the whole blood of pregnant women and suggests that PFHxS and PFUnDA may influence foetal growth and warrant further attention. Additional studies are required to identify the sources of PFAA exposure with a view to prevention, in addition to further studies investigating the long term health effects of these ubiquitous chemicals.
Keyword PFAAs
Whole blood
Birth weight
Maternal exposure
Proportion of optimal birth weight
Fetal growth
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID LP088936
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
National Research Centre for Environmental Toxicology Publications
 
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