The Walker 256 breast cancer cell-induced bone pain model in rats

Shenoy, Priyank A., Kuo, Andy, Vetter, Irina and Smith, Maree T. (2016) The Walker 256 breast cancer cell-induced bone pain model in rats. Frontiers in Pharmacology, 7 AUG: . doi:10.3389/fphar.2016.00286

Author Shenoy, Priyank A.
Kuo, Andy
Vetter, Irina
Smith, Maree T.
Title The Walker 256 breast cancer cell-induced bone pain model in rats
Journal name Frontiers in Pharmacology   Check publisher's open access policy
ISSN 1663-9812
Publication date 2016-08-31
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fphar.2016.00286
Open Access Status DOI
Volume 7
Issue AUG
Total pages 13
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Language eng
Subject 3004 Pharmacology
2736 Pharmacology (medical)
Abstract The majority of patients with terminal breast cancer show signs of bone metastasis, the most common cause of pain in cancer. Clinically available drug treatment options for the relief of cancer-associated bone pain are limited due to either inadequate pain relief and/or dose-limiting side-effects. One of the major hurdles in understanding the mechanism by which breast cancer causes pain after metastasis to the bones is the lack of suitable preclinical models. Until the late twentieth century, all animal models of cancer induced bone pain involved systemic injection of cancer cells into animals, which caused severe deterioration of animal health due to widespread metastasis. In this mini-review we have discussed details of a recently developed and highly efficient preclinical model of breast cancer induced bone pain: Walker 256 cancer cell- induced bone pain in rats. The model involves direct localized injection of cancer cells into a single tibia in rats, which avoids widespread metastasis of cancer cells and hence animals maintain good health throughout the experimental period. This model closely mimics the human pathophysiology of breast cancer induced bone pain and has great potential to aid in the process of drug discovery for treating this intractable pain condition.
Keyword Breast cancer
Bone pain
Walker 256 cell
Rat model
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID LP120200623
Institutional Status UQ

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