Concepts and misconceptions about the polygenic additive model applied to disease

Visscher, Peter M. and Wray, Naomi R. (2016) Concepts and misconceptions about the polygenic additive model applied to disease. Human Heredity, 80 4: 165-170. doi:10.1159/000446931


Author Visscher, Peter M.
Wray, Naomi R.
Title Concepts and misconceptions about the polygenic additive model applied to disease
Journal name Human Heredity   Check publisher's open access policy
ISSN 1423-0062
0001-5652
Publication date 2016-09-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1159/000446931
Open Access Status Not yet assessed
Volume 80
Issue 4
Start page 165
End page 170
Total pages 6
Place of publication Basel, Switzerland
Publisher S. Karger AG
Language eng
Abstract It is nearly one hundred years, since R.A. Fisher published his now famous paper that started the field of quantitative genetics. That paper reconciled Mendelian genetics (as exemplified by Mendel's peas) and the biometrical approach to quantitative traits (as exemplified by the correlation and regression approaches from Galton and Pearson), by showing that a simple model of many genes of small effects, each following Mendel's laws of segregation and inheritance, plus environmental variation could account for the observed resemblance between relatives. In this review, we discuss a number of concepts and misconceptions about the assumptions and limitations of polygenic models of common diseases in human populations.
Keyword Disease risk
Heritability of liability
Threshold model
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Institute for Molecular Bioscience - Publications
 
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