Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip

Combes, Alexander N., Lefevre, James G., Wilson, Sean, Hamilton, Nicholas A. and Little, Melissa H. (2016) Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip. Developmental Biology, 418 2: 297-306. doi:10.1016/j.ydbio.2016.06.028

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Author Combes, Alexander N.
Lefevre, James G.
Wilson, Sean
Hamilton, Nicholas A.
Little, Melissa H.
Title Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip
Journal name Developmental Biology   Check publisher's open access policy
ISSN 0012-1606
1095-564X
Publication date 2016-10-15
Sub-type Article (original research)
DOI 10.1016/j.ydbio.2016.06.028
Open Access Status File (Author Post-print)
Volume 418
Issue 2
Start page 297
End page 306
Total pages 10
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2017
Language eng
Abstract Morphogenesis of the mammalian kidney requires reciprocal interactions between two cellular domains at the periphery of the developing organ: the tips of the epithelial ureteric tree and adjacent regions of cap mesenchyme. While the presence of the cap mesenchyme is essential for ureteric branching, how it is specifically maintained at the tips is unclear. Using ex vivo timelapse imaging we show that cells of the cap mesenchyme are highly motile. Individual cap mesenchyme cells move within and between cap domains. They also attach and detach from the ureteric tip across time. Timelapse tracks collected for >800 cells showed evidence that this movement was largely stochastic, with cell autonomous migration influenced by opposing attractive, repulsive and cell adhesion cues. The resulting swarming behaviour maintains a distinct cap mesenchyme domain while facilitating dynamic remodelling in response to underlying changes in the tip.
Keyword Kidney development
Cap mesenchyme
Nephron progenitor
Cell migration
Live imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 30 Sep 2016, 23:27:02 EST by Susan Allen on behalf of Institute for Molecular Bioscience