Cell-cell fusion in the nervous system: alternative mechanisms of development, injury and repair

Giordano-Santini, Rosina, Linton, Casey and Hilliard, Massimo A. (2016) Cell-cell fusion in the nervous system: alternative mechanisms of development, injury and repair. Seminars in Cell and Developmental Biology, 60 146-154. doi:10.1016/j.semcdb.2016.06.019

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Author Giordano-Santini, Rosina
Linton, Casey
Hilliard, Massimo A.
Title Cell-cell fusion in the nervous system: alternative mechanisms of development, injury and repair
Journal name Seminars in Cell and Developmental Biology   Check publisher's open access policy
ISSN 1084-9521
1096-3634
Publication date 2016-06-29
Sub-type Article (original research)
DOI 10.1016/j.semcdb.2016.06.019
Open Access Status DOI
Volume 60
Start page 146
End page 154
Total pages 9
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2017
Language eng
Formatted abstract
Over a century ago, the seminal work of Ramón y Cajal revealed that the nervous system is made of individual units, the neurons, which are related to each other by contiguity rather than continuity. This view overturned the idea that the nervous system was a reticulum of fibers, a rete diffusa nervosa, as proposed and defined by Camillo Golgi. Although the neuron theory has been widely confirmed in every model system studied and constitutes the basis of modern neuroscience, evidence accumulated over the years suggests that neurons, similar to other types of cells, have the potential to fuse their membranes and undergo cell-cell fusion under certain conditions. This concept adds a substantial layer to our view of the nervous system and how it functions. Here, we bring together past and more recent discoveries on multiple aspects of neuronal fusion, discussing how this cellular event is generated, and what consequences it has for our understanding of nervous system development, disease, injury, and repair.
Keyword Cell-cell fusion
Axonal regeneration
Dendrite remodelling
Heterokaryon
Neuron theory
Fusogen
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Centre for Ageing Dementia Research Publications
 
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Created: Wed, 28 Sep 2016, 02:58:58 EST by Kirstie Asmussen on behalf of School of Music