Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex

Fenton, Georgina E., Halliday, David M., Mason, Rob, Bredy, Timothy W. and Stevenson, Carl W. (2016) Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex. Neurobiology of Learning and Memory, 135 66-72. doi:10.1016/j.nlm.2016.06.019

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Author Fenton, Georgina E.
Halliday, David M.
Mason, Rob
Bredy, Timothy W.
Stevenson, Carl W.
Title Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
Journal name Neurobiology of Learning and Memory   Check publisher's open access policy
ISSN 1074-7427
1095-9564
Publication date 2016-06-21
Sub-type Article (original research)
DOI 10.1016/j.nlm.2016.06.019
Open Access Status File (Author Post-print)
Volume 135
Start page 66
End page 72
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2017
Language eng
Formatted abstract
Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female rats. Emerging evidence indicates that gamma oscillations in mPFC are also implicated in the expression and extinction of learned fear. Therefore we re-examined our in vivo electrophysiology data and found that females showed persistent PL gamma activation during extinction and a failure of IL gamma activation during extinction recall. Altered prefrontal gamma oscillations thus accompany sex differences in learned fear expression and its extinction. These findings are relevant for understanding the neural basis of post-traumatic stress disorder, which is more prevalent in women and involves impaired extinction and mPFC dysfunction.
Keyword Sex differences
Fear conditioning
Extinction
Prelimbic
Infralimbic
Gamma oscillations
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Wed, 28 Sep 2016, 02:30:27 EST by Kirstie Asmussen on behalf of School of Music