Genetic heterogeneity in autism: from single gene to a pathway perspective

An, Joon Yong and Claudianos, Charles (2016) Genetic heterogeneity in autism: from single gene to a pathway perspective. Neuroscience and Biobehavioral Reviews, 68 442-453. doi:10.1016/j.neubiorev.2016.06.013


Author An, Joon Yong
Claudianos, Charles
Title Genetic heterogeneity in autism: from single gene to a pathway perspective
Journal name Neuroscience and Biobehavioral Reviews   Check publisher's open access policy
ISSN 0149-7634
1873-7528
Publication date 2016-09-01
Sub-type Article (original research)
DOI 10.1016/j.neubiorev.2016.06.013
Open Access Status Not yet assessed
Volume 68
Start page 442
End page 453
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Subject 3206 Neuropsychology and Physiological Psychology
2805 Cognitive Neuroscience
2802 Behavioral Neuroscience
Abstract The extreme genetic heterogeneity of autism spectrum disorder (ASD) represents a major challenge. Recent advances in genetic screening and systems biology approaches have extended our knowledge of the genetic etiology of ASD. In this review, we discuss the paradigm shift from a single gene causation model to pathway perturbation model as a guide to better understand the pathophysiology of ASD. We discuss recent genetic findings obtained through next-generation sequencing (NGS) and examine various integrative analyses using systems biology and complex networks approaches that identify convergent patterns of genetic elements associated with ASD.
Keyword Autism Spectrum disorders (ASD)
Brain gene expression
Genome sequencing
Neurodevelopment
Systems biology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1008125
FT110100292
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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Created: Wed, 28 Sep 2016, 01:16:33 EST by Kirstie Asmussen on behalf of School of Music