Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae).

Bowles, Vernon M., Yoon, Kyong Sup, Barker, Stephen C., Tran, Christopher, Rhodes, Christopher and Clark, Marshall J. (2016) Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae).. Journal Of Medical Entomology, 54 1: 167-172. doi:10.1093/jme/tjw132

Author Bowles, Vernon M.
Yoon, Kyong Sup
Barker, Stephen C.
Tran, Christopher
Rhodes, Christopher
Clark, Marshall J.
Title Ovicidal Efficacy of Abametapir Against Eggs of Human Head and Body Lice (Anoplura: Pediculidae).
Journal name Journal Of Medical Entomology   Check publisher's open access policy
ISSN 0022-2585
Publication date 2016-08-21
Sub-type Article (original research)
DOI 10.1093/jme/tjw132
Open Access Status Not yet assessed
Volume 54
Issue 1
Start page 167
End page 172
Total pages 6
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Abstract Studies were undertaken to determine the ovicidal efficacy of 5,5′-dimethyl-2,2′-bipyridyl (abametapir) against eggs of both human head and body lice. Head lice eggs of different ages (0–2, 3–5, and 6–8-d-old eggs) were exposed to varying concentrations of abametapir in isopropanol and concentration-dependent response relationships established based on egg hatch. One hundred percent of all abametapir-treated eggs failed to hatch at the 0.74 and 0.55% concentrations, whereas 100% of 6–8-d-old head louse eggs failed to hatch only at the 0.74% concentration. The LC50 value for abametapir varied, depending on the age of the head lice eggs, from ∼0.10% recorded for 0–2-d-old eggs and increasing to ∼0.15% for 6–8-d-old eggs. Abametapir was also evaluated once formulated into a lotion referred to as Xeglyze (0.74% abametapir) and serial dilutions made. Ovicidal efficacies were determined against head lice eggs 0–8-d-old. Results indicated 100% ovicidal activity at the 0.74, 0.55, 0.37, and 0.18% concentrations. Additional studies undertaken using body lice eggs also demonstrated that abametapir was 100% ovicidal against eggs of all ages when evaluated at a concentration of 0.37 and 0.55%. Given that ovicidal activity is a critical component of any effective treatment regime for louse control, the data presented in this study clearly demonstrate the ability of abametapir to inhibit hatching of both head and body louse eggs as assessed in vitro.
Keyword Body louse (Pediculus humanus)
Head louse (Pediculus capitis)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 27 Sep 2016, 21:07:30 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences