INFLUENCE OF SEASON AND ANAESTHETIC ON CUTANEOUS VASCULAR PERMEABILITY RESPONSES TO HISTAMINE, SEROTONIN AND MAST CELL‐RELEASING AGENTS IN RATS

Chahl L.A. (1983) INFLUENCE OF SEASON AND ANAESTHETIC ON CUTANEOUS VASCULAR PERMEABILITY RESPONSES TO HISTAMINE, SEROTONIN AND MAST CELL‐RELEASING AGENTS IN RATS. Clinical and Experimental Pharmacology and Physiology, 10 4: 415-420. doi:10.1111/j.1440-1681.1983.tb00846.x


Author Chahl L.A.
Title INFLUENCE OF SEASON AND ANAESTHETIC ON CUTANEOUS VASCULAR PERMEABILITY RESPONSES TO HISTAMINE, SEROTONIN AND MAST CELL‐RELEASING AGENTS IN RATS
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 1440-1681
Publication date 1983-01-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.1983.tb00846.x
Open Access Status Not yet assessed
Volume 10
Issue 4
Start page 415
End page 420
Total pages 6
Subject 1314 Physiology
3004 Pharmacology
2737 Physiology (medical)
Abstract The influences of season and anaesthetic on the cutaneous vascular permeability responses to histamine (2.5 × 10−8 mol), serotonin (5HT, 2.5 × 10−10 mol), and to the mast cell‐releasing agents adenosine 51‐triphosphate (2.5 × 10−7 mol), dextran (5 × 10−5 g) and compound 48/80 (1 × 10−7 g) were examined using an Evans blue dye leakage technique. In rats anaesthetized with urethane (1 g/kg i.p.), responses to irritants were significantly less than in rats given ether for the period of administration of irritants and allowed to recover consciousness. The response to histamine was mediated by Hi‐receptors since it was abolished by mepyramine but not by metiamide. The only seasonal variation observed was in responses to 5HT in urethane‐anaesthetized rats, which were significantly less in winter than in summer. It was concluded that dye leakage responses to irritants are affected more by anaesthetic than by seasonal variation. Copyright
Keyword anaesthetics
cutaneous vascular permeability
histamine
mast cell‐releasers
season
serotonin
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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