Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

Schmaal, L., Hibar, D. P., Samann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N., Cheung, J. W., van Erp, T. G. M., Bos, D., Ikram, M. A., Vernooij, M. W., Niessen, W. J., Tiemeier, H., Hofman, A., Wittfeld, K., Grabe, H. J., Janowitz, D., Bulow, R., Selonke, M., Volzke, H., Grotegerd, D., Dannlowski, U., Arolt, V., Opel, N., Heindel, W., Kugel, H., Hoehn, D., Czisch, M., Couvy-Duchesne, B., Renteria, M. E., Strike, L. T., Wright, M. J., Mills, N. T., de Zubicaray, G. I., McMahon, K. L., Medland, S. E., Martin, N. G., Gillespie, N. A., Goya-Maldonado, R., Gruber, O., Kramer, B., Hatton, S. N., Lagopoulos, J., Hickie, I. B., Frodl, T., Carballedo, A., Frey, E. M., van Velzen, L. S., Penninx, B. W. J. H., van Tol, M. J., van der Wee, N. J., Davey, C. G., Harrison, B. J., Mwangi, B., Cao, B., Soares, J. C., Veer, I. M., Walter, H., Schoepf, D., Zurowski, B., Konrad, C., Schramm, E., Normann, C., Schnell, K., Sacchet, M. D., Gotlib, I. H., MacQueen, G. M., Godlewska, B. R., Nickson, T., McIntosh, A. M., Papmeyer, M., Whalley, H. C., Hall, J., Sussmann, J. E., Li, M., Walter, M., Aftanas, L., Brack, I., Bokhan, N. A., Thompson, P. M. and Veltman, D. J. (2016) Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. Molecular Psychiatry, 22 6: 900-909. doi:10.1038/mp.2016.60

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Author Schmaal, L.
Hibar, D. P.
Samann, P. G.
Hall, G. B.
Baune, B. T.
Jahanshad, N.
Cheung, J. W.
van Erp, T. G. M.
Bos, D.
Ikram, M. A.
Vernooij, M. W.
Niessen, W. J.
Tiemeier, H.
Hofman, A.
Wittfeld, K.
Grabe, H. J.
Janowitz, D.
Bulow, R.
Selonke, M.
Volzke, H.
Grotegerd, D.
Dannlowski, U.
Arolt, V.
Opel, N.
Heindel, W.
Kugel, H.
Hoehn, D.
Czisch, M.
Couvy-Duchesne, B.
Renteria, M. E.
Strike, L. T.
Wright, M. J.
Mills, N. T.
de Zubicaray, G. I.
McMahon, K. L.
Medland, S. E.
Martin, N. G.
Gillespie, N. A.
Goya-Maldonado, R.
Gruber, O.
Kramer, B.
Hatton, S. N.
Lagopoulos, J.
Hickie, I. B.
Frodl, T.
Carballedo, A.
Frey, E. M.
van Velzen, L. S.
Penninx, B. W. J. H.
van Tol, M. J.
van der Wee, N. J.
Davey, C. G.
Harrison, B. J.
Mwangi, B.
Cao, B.
Soares, J. C.
Veer, I. M.
Walter, H.
Schoepf, D.
Zurowski, B.
Konrad, C.
Schramm, E.
Normann, C.
Schnell, K.
Sacchet, M. D.
Gotlib, I. H.
MacQueen, G. M.
Godlewska, B. R.
Nickson, T.
McIntosh, A. M.
Papmeyer, M.
Whalley, H. C.
Hall, J.
Sussmann, J. E.
Li, M.
Walter, M.
Aftanas, L.
Brack, I.
Bokhan, N. A.
Thompson, P. M.
Veltman, D. J.
Title Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1476-5578
1359-4184
Publication date 2016-03-03
Year available 2017
Sub-type Article (original research)
DOI 10.1038/mp.2016.60
Open Access Status DOI
Volume 22
Issue 6
Start page 900
End page 909
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.
Formatted abstract
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen’s d effect sizes: −0.10 to −0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: −0.26 to −0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.
Keyword Biochemistry & Molecular Biology
Neurosciences
Psychiatry
Biochemistry & Molecular Biology
Neurosciences & Neurology
Psychiatry
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 104036
MR/K026992/1
U54 EB020403
R01 HD050735
R01 MH059259
Institutional Status UQ

 
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