Age of onset and lifetime projected risk of psychotic experiences: cross-national data from the World Mental Health survey

McGrath, John J., Saha, Sukanta, Al-Hamzawi, Ali O., Alonso, Jordi, Andrade, Laura, Borges, Guilherme, Brome, Evelyn J., Oakley Browne, Mark, Bruffaerts, Ronny, Caldas de Almeida, Jose M., Fayyad, John, Florescu, Silvia, de Girolamo, Giovanni, Gureje, Oye, Hu, Chiyi, de Jonge, Peter, Kovess-Masfety, Viviane, Lepine, Jean Pierre, Lim, Carmen C. W, Navarro-Mateu, Fernando, Piazza, Maria, Sampson, Nancy, Posada-Villa, José, Kendler, Kenneth S. and Kessler, Ronald C. (2016) Age of onset and lifetime projected risk of psychotic experiences: cross-national data from the World Mental Health survey. Schizophrenia Bulletin, 42 4: 933-941. doi:10.1093/schbul/sbw011

Author McGrath, John J.
Saha, Sukanta
Al-Hamzawi, Ali O.
Alonso, Jordi
Andrade, Laura
Borges, Guilherme
Brome, Evelyn J.
Oakley Browne, Mark
Bruffaerts, Ronny
Caldas de Almeida, Jose M.
Fayyad, John
Florescu, Silvia
de Girolamo, Giovanni
Gureje, Oye
Hu, Chiyi
de Jonge, Peter
Kovess-Masfety, Viviane
Lepine, Jean Pierre
Lim, Carmen C. W
Navarro-Mateu, Fernando
Piazza, Maria
Sampson, Nancy
Posada-Villa, José
Kendler, Kenneth S.
Kessler, Ronald C.
Title Age of onset and lifetime projected risk of psychotic experiences: cross-national data from the World Mental Health survey
Journal name Schizophrenia Bulletin   Check publisher's open access policy
ISSN 0586-7614
Publication date 2016-07-01
Sub-type Article (original research)
DOI 10.1093/schbul/sbw011
Open Access Status Not yet assessed
Volume 42
Issue 4
Start page 933
End page 941
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2017
Language eng
Formatted abstract
Background: Given the early age of onset (AOO) of psychotic disorders, it has been assumed that psychotic experiences (PEs) would have a similar early AOO. The aims of this study were to describe (a) the AOO distribution of PEs, (b) the projected lifetime risk of PEs, and (c) the associations of PE AOO with selected PE features.

Methods: Data came from the WHO World Mental Health (WMH) surveys. A total of 31 261 adult respondents across 18 countries were assessed for lifetime prevalence of PE. Projected lifetime risk (at age 75 years) was estimated using a 2-part actuarial method. AOO distributions were described for the observed and projected estimates. We examined associations of AOO with PE type metric and annualized PE frequency.

Results: Projected lifetime risk for PEs was 7.8% (SE = 0.3), slightly higher than lifetime prevalence (5.8%, SE = 0.2). The median (interquartile range; IQR) AOO based on projected lifetime estimates was 26 (17–41) years, indicating that PEs commence across a wide age range. The AOO distributions for PEs did not differ by sex. Early AOO was positively associated with number of PE types (F = 14.1, P < .001) but negatively associated with annualized PE frequency rates (F = 8.0, P < .001).

Discussion: While most people with lifetime PEs have first onsets in adolescence or young adulthood, projected estimates indicate that nearly a quarter of first onsets occur after age 40 years. The extent to which late onset PEs are associated with (a) late onset mental disorders or (b) declining cognitive and/or sensory function need further research.
Keyword Epidemiology
Psychotic experiences
Age of onset
Lifetime prevalence
World Mental Health Survey
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 27 Sep 2016, 00:58:41 EST by Kirstie Asmussen on behalf of School of Music