Diabetes mellitus and hypertension: a dual threat

Oktay, Ahmet Afsin, Akturk, Halis Kaan and Jahangir, Eiman (2016) Diabetes mellitus and hypertension: a dual threat. Current Opinion in Cardiology, 31 4: 402-409. doi:10.1097/HCO.0000000000000297

Author Oktay, Ahmet Afsin
Akturk, Halis Kaan
Jahangir, Eiman
Title Diabetes mellitus and hypertension: a dual threat
Journal name Current Opinion in Cardiology   Check publisher's open access policy
ISSN 1531-7080
Publication date 2016-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/HCO.0000000000000297
Open Access Status Not yet assessed
Volume 31
Issue 4
Start page 402
End page 409
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Purpose of review: The following is a review of the current concepts on the relationship between hypertension (HTN) and diabetes mellitus with a focus on the epidemiology and cardiovascular prognostic implications of coexistent HTN and diabetes mellitus, shared mechanisms underlying both conditions and pathophysiology of increased risk of cardiovascular disease, treatment of HTN in individuals with diabetes mellitus, and effects of anti-diabetic medications on blood pressure (BP).

Recent findings: Diabetes mellitus and HTN often coexist in the same individual. They share numerous risk factors and underlying pathophysiologic mechanisms, most important of which are insulin resistance and inappropriate activation of the rennin-angiotensin-aldosterone system. Recently updated guidelines recommend a BP goal of 140/90 mmHg in most individuals with diabetes mellitus. A new class of anti-diabetic medications, sodium-glucose co-transporter 2 inhibitors, has shown favorable effects on BP.

Summary: HTN affects the majority of individuals with diabetes mellitus. Coexistence of diabetes mellitus and HTN, especially if BP is not well controlled, dramatically increases the risk of morbidity and mortality from cardiovascular disease. BP control is an essential part of management of patients with diabetes mellitus, because it is one of the most effective ways to prevent vascular complications and death.
Keyword Antihypertensive agents
Blood pressure
Cardiovascular diseases
Diabetes mellitus
Insulin resistance
Renin-angiotensin system
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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