Targeting natural killer cells in cancer immunotherapy

Guillerey, Camille, Huntington, Nicholas D. and Smyth, Mark J. (2016) Targeting natural killer cells in cancer immunotherapy. Nature Immunology, 17 9: 1025-1036. doi:10.1038/ni.3518

Author Guillerey, Camille
Huntington, Nicholas D.
Smyth, Mark J.
Title Targeting natural killer cells in cancer immunotherapy
Journal name Nature Immunology   Check publisher's open access policy
ISSN 1529-2916
Publication date 2016-08-19
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/ni.3518
Open Access Status Not yet assessed
Volume 17
Issue 9
Start page 1025
End page 1036
Total pages 12
Place of publication New York, NY United States
Publisher Nature Publishing Group
Language eng
Abstract Alteration in the expression of cell-surface proteins is a common consequence of malignant transformation. Natural killer (NK) cells use an array of germline-encoded activating and inhibitory receptors that scan for altered protein-expression patterns, but tumor evasion of detection by the immune system is now recognized as one of the hallmarks of cancer. NK cells display rapid and potent immunity to metastasis or hematological cancers, and major efforts are now being undertaken to fully exploit NK cell anti-tumor properties in the clinic. Diverse approaches encompass the development of large-scale NK cell–expansion protocols for adoptive transfer, the establishment of a microenvironment favorable to NK cell activity, the redirection of NK cell activity against tumor cells and the release of inhibitory signals that limit NK cell function. In this Review we detail recent advances in NK cell–based immunotherapies and discuss the advantages and limitations of these strategies.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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