Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?

Zhuang, Aowen and Forbes, Josephine M. (2016) Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?. Glycoconjugate Journal, 33 4: 645-652. doi:10.1007/s10719-016-9693-z


Author Zhuang, Aowen
Forbes, Josephine M.
Title Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?
Journal name Glycoconjugate Journal   Check publisher's open access policy
ISSN 1573-4986
0282-0080
Publication date 2016-08-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s10719-016-9693-z
Open Access Status Not yet assessed
Volume 33
Issue 4
Start page 645
End page 652
Total pages 8
Place of publication New York, NY, United States
Publisher Springer New York LLC
Language eng
Abstract Diabetic patients are postulated to be in a perpetual state of oxidative stress and inflammation at sites where chronic complications occur. The accumulation of AGEs derived from both endogenous and exogenous sources (such as the diet) have been implicated in the development and progression of diabetic complications, particularly nephropathy. There has been some interest in investigating the potential for reducing the AGE burden in chronic disease, through the action of AGE “clearance” receptors, such as the advanced glycation end-product receptor 1 (AGE-R1). Reducing the burden of AGEs has been linked to attenuation of inflammation, slower progression of diabetic complications (in particular vascular and renal complications) and has been shown to extend lifespan. To date, however, there have been no direct investigations into whether AGE-R1 has any role in modulating normal kidney function, or specifically during the development and progression of diabetes. This mini-review will focus on the recent advances in knowledge around the mechanistic function of AGE-R1 and the implications of this for the pathogenesis of diabetic kidney disease.
Keyword AGE-R1
AGEs
Diabetes
Diabetic kidney disease
Diabetic nephropathy
OST-48
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 18 Sep 2016, 10:23:35 EST by System User on behalf of Learning and Research Services (UQ Library)