Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly

Adler-Abramovich, Lihi, Marco, Pini, Amon, Zohar A., Creasey, Rhiannon C. G., Michaels, Thomas C. T., Levin, Aviad, Scurr, David J., Roberts, Clive J., Knowles, Tuomas P. J., Tendler, Saul J. B. and Gazit, Ehud (2016) Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly. ACS Nano, 10 8: 7436-7442. doi:10.1021/acsnano.6b01587

Author Adler-Abramovich, Lihi
Marco, Pini
Amon, Zohar A.
Creasey, Rhiannon C. G.
Michaels, Thomas C. T.
Levin, Aviad
Scurr, David J.
Roberts, Clive J.
Knowles, Tuomas P. J.
Tendler, Saul J. B.
Gazit, Ehud
Title Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly
Journal name ACS Nano   Check publisher's open access policy
ISSN 1936-086X
Publication date 2016-08-23
Year available 2016
Sub-type Article (original research)
DOI 10.1021/acsnano.6b01587
Open Access Status Not yet assessed
Volume 10
Issue 8
Start page 7436
End page 7442
Total pages 7
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Subject 2500 Materials Science
2200 Engineering
3100 Physics and Astronomy
Abstract Molecular self-assembly of peptides into ordered nanotubes is highly important for various technological applications. Very short peptide building blocks, as short as dipeptides, can form assemblies with unique mechanical, optical, piezoelectric, and semiconductive properties. Yet, the control over nanotube length in solution has remained challenging, due to the inherent sequential self-assembly mechanism. Here, in line with polymer chemistry paradigms, we applied a supramolecular polymer coassembly methodology to modulate peptide nanotube elongation. Utilizing this approach, we achieved a narrow, controllable nanotube length distribution by adjusting the molecular ratio of the diphenylalanine assembly unit and its end-capped analogue. Kinetic analysis suggested a slower coassembly organization process as compared to the self-assembly dynamics of each of the building blocks separately. This is consistent with a hierarchal arrangement of the peptide moieties within the coassemblies. Mass spectrometry analysis demonstrated the bimolecular composition of the coassembled nanostructures. Moreover, the peptide nanotubes' length distribution, as determined by electron microscopy, was shown to fit a fragmentation kinetics model. Our results reveal a simple and efficient mechanism for the control of nanotube sizes through the coassembly of peptide entities at various ratios, allowing for the desired end-product formation. This dynamic size control offers tools for molecular engineering at the nanoscale exploiting the advantages of molecular coassembly.
Keyword Coassembly
Peptide nanotubes
Supramolecular polymers
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
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