Connections between the gut microbiome and metabolic hormones in early pregnancy in overweight and obese women

Gomez-Arango, Luisa F., Barrett, Helen L., McIntyre, H. David, Callaway, Leonie K., Morrison, Mark and Dekker Nitert, Marloes (2016) Connections between the gut microbiome and metabolic hormones in early pregnancy in overweight and obese women. Diabetes, 65 8: 2214-2223. doi:10.2337/db16-0278


Author Gomez-Arango, Luisa F.
Barrett, Helen L.
McIntyre, H. David
Callaway, Leonie K.
Morrison, Mark
Dekker Nitert, Marloes
Title Connections between the gut microbiome and metabolic hormones in early pregnancy in overweight and obese women
Journal name Diabetes   Check publisher's open access policy
ISSN 1939-327X
0012-1797
Publication date 2016-08-01
Sub-type Article (original research)
DOI 10.2337/db16-0278
Open Access Status Not yet assessed
Volume 65
Issue 8
Start page 2214
End page 2223
Total pages 10
Place of publication Alexandria, VA, United States
Publisher American Diabetes Association
Collection year 2017
Language eng
Formatted abstract
Overweight and obese women are at a higher risk for gestational diabetes mellitus. The gut microbiome could modulate metabolic health and may affect insulin resistance and lipid metabolism. The aim of this study was to reveal relationships between gut microbiome composition and circulating metabolic hormones in overweight and obese pregnant women at 16 weeks' gestation. Fecal microbiota profiles from overweight (n = 29) and obese (n = 41) pregnant women were assessed by 16S rRNA sequencing. Fasting metabolic hormone (insulin, C-peptide, glucagon, incretin, and adipokine) concentrations were measured using multiplex ELISA. Metabolic hormone levels as well as microbiome profiles differed between overweight and obese women. Furthermore, changes in some metabolic hormone levels were correlated with alterations in the relative abundance of specific microbes. Adipokine levels were strongly correlated with Ruminococcaceae and Lachnospiraceae, which are dominant families in energy metabolism. Insulin was positively correlated with the genus Collinsella. Gastrointestinal polypeptide was positively correlated with the genus Coprococcus but negatively with family Ruminococcaceae. This study shows novel relationships between gut microbiome composition and the metabolic hormonal environment in overweight and obese pregnant women at 16 weeks' gestation. These results suggest that manipulation of the gut microbiome composition may influence pregnancy metabolism.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 18 Sep 2016, 10:18:18 EST by System User on behalf of Learning and Research Services (UQ Library)