Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release

Osei-Kumah, Annette, Wark, Peter A. B., Smith, Roger and Clifton, Vicki L. (2010) Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release. Inflammation Research, 59 5: 349-358. doi:10.1007/s00011-009-0102-y


Author Osei-Kumah, Annette
Wark, Peter A. B.
Smith, Roger
Clifton, Vicki L.
Title Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release
Journal name Inflammation Research   Check publisher's open access policy
ISSN 1023-3830
1420-908X
Publication date 2010-05-01
Year available 2009
Sub-type Article (original research)
DOI 10.1007/s00011-009-0102-y
Open Access Status Not yet assessed
Volume 59
Issue 5
Start page 349
End page 358
Total pages 10
Place of publication Basel, Switzerland
Publisher Springer Basel AG
Language eng
Formatted abstract
Objective: Pregnancy can influence the course of maternal asthma, but the mechanisms are presently unknown. The aim of the present study was to access maternal immune cell profiles in the presence and absence of asthma and to determine the effect of pregnancy-derived factors on epithelial cell function.

Methods: Cells from the human bronchial epithelial cell line BEAS-2B were treated with plasma from pregnant or nonpregnant asthmatic and nonasthmatic subjects. Cell culture supernatants were collected after 24 h and assayed for IL-6, IL-8, eotaxin, RANTES and sICAM-1 protein using ELISA. Maternal immune cell count and peripheral blood chemotactic response to plasma from pregnant and non-pregnant asthmatic subjects were also assessed.

Results: The presence of maternal asthma during pregnancy was associated with increased monocyte and neutrophil numbers, increased BEAS-2B cell production of IL-8 and sICAM-1 (P<0.05) and increased chemotactic capacity relative to pregnant women without asthma.

Conclusion: The results of this study suggest that circulating pregnancy-related factors enhance chemotactic mediators in epithelial cells in the presence of asthma. This may be one mechanism that contributes to pregnancyinduced changes in asthma.
Keyword Bronchial epithelium
Chemokine
Chemotaxis
Immune cells
Pregnancy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
 
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