Review: the feto-placental unit, pregnancy pathology and impact on long term maternal health

Clifton, V. L., Stark, M. J., Osei-Kumah, A. and Hodyl, N. A. (2012) Review: the feto-placental unit, pregnancy pathology and impact on long term maternal health. Placenta, 33 Supplement: S37-S41. doi:10.1016/j.placenta.2011.11.005


Author Clifton, V. L.
Stark, M. J.
Osei-Kumah, A.
Hodyl, N. A.
Title Review: the feto-placental unit, pregnancy pathology and impact on long term maternal health
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
1532-3102
Publication date 2012-02-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.placenta.2011.11.005
Open Access Status Not yet assessed
Volume 33
Issue Supplement
Start page S37
End page S41
Total pages 5
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Abstract Pregnancy induces a number of alterations to maternal physiology to accommodate the increased demands made by the developing fetus and placenta. These alterations appear at least in part to be driven by products derived from the feto-placental unit, including microchimeric cells, as well as placental exosomes and microparticles, inducing changes to maternal physiology both during pregnancy and beyond. Further, increasing evidence suggests that some of these alterations are dependent on the sex of the fetus. Pre-eclampsia and asthma represent two common pregnancy complications that have provided valuable insight into how the feto-placental unit influences maternal physiology in a sex-specific manner. Pregnancy-induced alterations in maternal physiology may expose pre-existing subclinical pathologies and provide insight into future maternal health and disease. While most pregnancy-induced alterations to the maternal system are reversed following delivery, some can persist after parturition leading to cardiovascular, metabolic and autoimmune disease and increased risk of early mortality.
Keyword Adaptations
Maternal physiology
Placenta
Pregnancy
Sex-specific differences
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 1016379
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Mater Research Institute-UQ (MRI-UQ)
 
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