Some effects of crude venom from the cones Conus striatus and Conus magus on isolated guinea-pig atria

Endean R., Surridge J. and Gyr P. (1977) Some effects of crude venom from the cones Conus striatus and Conus magus on isolated guinea-pig atria. Toxicon, 15 5: 369-374. doi:10.1016/0041-0101(77)90113-1


Author Endean R.
Surridge J.
Gyr P.
Title Some effects of crude venom from the cones Conus striatus and Conus magus on isolated guinea-pig atria
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 1977-01-01
Sub-type Article (original research)
DOI 10.1016/0041-0101(77)90113-1
Volume 15
Issue 5
Start page 369
End page 374
Total pages 6
Subject 3005 Toxicology
Abstract Long-lasting positive inotropic activity is shown by the venoms of Conus striatus and C. magus. The activity persists after repeated and prolonged washout but is blocked by prior β-adrenoceptor blockade with propranolol and also by the 5-hydroxytryptamine antagonist BOL-148. The activity is not exerted on atria from reserpinized animals. It is suggested that the activity stems from an ability of each venom to release monoamines from cardiac tissues. In addition to their positive inotropic activity the venoms also induce spontaneous contractions in isolated atria. These contractions are not blocked by propranolol or BOL-148.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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