INFLUENCE OF ALCOHOL AND CAFFEINE CONSUMPTION ON CAFFEINE ELIMINATION

George J., Murphy T., Roberts R., Cooksley W.G.E., Halliday J.W. and Powell L.W. (1986) INFLUENCE OF ALCOHOL AND CAFFEINE CONSUMPTION ON CAFFEINE ELIMINATION. Clinical and Experimental Pharmacology and Physiology, 13 10: 731-736. doi:10.1111/j.1440-1681.1986.tb02414.x


Author George J.
Murphy T.
Roberts R.
Cooksley W.G.E.
Halliday J.W.
Powell L.W.
Title INFLUENCE OF ALCOHOL AND CAFFEINE CONSUMPTION ON CAFFEINE ELIMINATION
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 1440-1681
Publication date 1986-01-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.1986.tb02414.x
Open Access Status Not yet assessed
Volume 13
Issue 10
Start page 731
End page 736
Total pages 6
Subject 1314 Physiology
3004 Pharmacology
2737 Physiology (medical)
Abstract 1. Ten healthy male volunteers were each studied on four separate occasions to assess the role of regular caffeine and alcohol intake on caffeine elimination. Antipyrine disappearance was also studied as an established quantitative test of hepatic microsomal function. 2. Regular caffeine intake in high doses for 1 week failed to alter either antipyrine or caffeine pharmacokinetics. 3. In contrast, alcohol intake of 50 g/day significantly prolonged caffeine half‐life by 72% (P<0.005) and diminished caffeine clearance by 36% (P<0.0005). However, antipyrine kinetics were unaltered. 4. These results demonstrate that alcohol, in amounts commonly consumed, is a strong inhibitor of caffeine metabolism. Copyright
Keyword alcohol
antipyrine
caffeine
drug metabolism.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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