Lack of production of thromboxane A2 by the sheep heart following coronary occlusion

Carter J., Reynoldson J.A., Harper C.M., Heywood L.H. and Thorburn G.D. (1986) Lack of production of thromboxane A2 by the sheep heart following coronary occlusion. Comparative Biochemistry and Physiology. Part C, Comparative, 83 2: 387-392. doi:10.1016/0742-8413(86)90141-6


Author Carter J.
Reynoldson J.A.
Harper C.M.
Heywood L.H.
Thorburn G.D.
Title Lack of production of thromboxane A2 by the sheep heart following coronary occlusion
Journal name Comparative Biochemistry and Physiology. Part C, Comparative   Check publisher's open access policy
ISSN 0306-4492
Publication date 1986-01-01
Sub-type Article (original research)
DOI 10.1016/0742-8413(86)90141-6
Volume 83
Issue 2
Start page 387
End page 392
Total pages 6
Subject 3004 Pharmacology
2403 Immunology
Abstract 1. Blood pressure, heart rate and ECG were monitored continuously and coronary venous blood samples assayed for thromboxane B2. Arterio-coronary venous lactic acid differences were estimated. 2. In anaesthetized sheep, 60 sec occlusions of the left circumflex coronary artery caused hypotension with little change in heart rate. Five minute occlusions produced similar changes accompanied by cardiac arrhythmias and a larger fall in blood pressure. 3. In conscious sheep heart rate rose and blood pressure was maintained. 4. ECG and lactic acid changes indicated severe myocardial ischaemia but no change in thromboxane release was detected. 5. The apparent lack of involvement of thromboxane may reflect a relative inability of sheep platelets to produce this substance or a failure to provide an adequate stimulus for synthesis.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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