Ataxia telangiectasia: An anomaly in DNA replication after irradiation

Ford M.D. and Lavin M.F. (1981) Ataxia telangiectasia: An anomaly in DNA replication after irradiation. Nucleic Acids Research, 9 6: 1395-1404. doi:10.1093/nar/9.6.1395


Author Ford M.D.
Lavin M.F.
Title Ataxia telangiectasia: An anomaly in DNA replication after irradiation
Journal name Nucleic Acids Research   Check publisher's open access policy
ISSN 0305-1048
Publication date 1981-03-25
Sub-type Article (original research)
DOI 10.1093/nar/9.6.1395
Open Access Status DOI
Volume 9
Issue 6
Start page 1395
End page 1404
Total pages 10
Subject 1804 Statistics, Probability and Uncertainty
2604 Applied Mathematics
2307 Health, Toxicology and Mutagenesis
3005 Toxicology
2716 Genetics (clinical)
1311 Genetics
Abstract The effect of increasing dose of γ-radiation on DNA synthesis in an ataxia telangiectasia lymphoblastoid cell line and a number of control lymphoblastoid cell lines was investigated. No significant inhibition of low molecular weight DNA synthesis was observed in the AT cell line at doses which resulted in considerable inhibition in the control cell lines. At higher doses, 600 to 800 rads, low molecular weight DNA synthesis and chain elongation were enhanced in the AT cell line. A time course study of DNA synthesis after 200 rads of γ-radiation, revealed no appreciable inhibition of low and high molecular weight DNA synthesis up to 60 minutes postirradiation. However, in control cell lines, overall DNA synthesis was depressed to a level 50% of that shown by the un-irradiated cells.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 13 Sep 2016, 14:30:05 EST by System User