Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension

Wanstall J.C. and O'Donnell S.R. (1990) Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension. European Journal of Pharmacology, 176 2: 159-168. doi:10.1016/0014-2999(90)90524-A


Author Wanstall J.C.
O'Donnell S.R.
Title Endothelin and 5-hydroxytryptamine on rat pulmonary artery in pulmonary hypertension
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 1990-02-06
Sub-type Article (original research)
DOI 10.1016/0014-2999(90)90524-A
Volume 176
Issue 2
Start page 159
End page 168
Total pages 10
Language eng
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
Abstract Contractile responses to endothelin, 5-hydroxytryptamine (5-HT), noradrenaline and potassium were obtained on isolated preparations of pulmonary artery from rats made pulmonary hypertensive by an injection of monocrotaline (105 mg/kg s.c.) 4 weeks previously. When compared with data obtained in control rats, the potencies (negative log EC50 values) for 5-HT, noradrenaline and potassium were increased (30, 3- and 3-fold, respectively), and the maximum contractions (mN/mm2) to endothelin, noradrenaline and potassium were reduced (65, 40 and 45% reduction). These changes were not seen 2 weeks after injection of monocrotaline, before pulmonary hypertension developed, or in preparations of aorta. It is concluded that monocrotaline-induced pulmonary hypertension affects pulmonary vascular responsiveness to spasmogens differentially. The comparative importance of endothelin and 5-HT as pulmonary vasoconstrictors may change in monocrotaline-induced pulmonary hypertension, there being an increase in responsiveness to 5-HT and a decrease in responsiveness to endothelin.
Keyword 5-Hydroxytryptamine
Endothelin
Monocrotaline
Pulmonary artery (rat)
Pulmonary hypertension
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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