Effect of amitraz and its metabolites on intestinal motility

Pass M.A. and Mogg T.D. (1991) Effect of amitraz and its metabolites on intestinal motility. Comparative Biochemistry and Physiology. Part C, Comparative, 99 1-2: 169-172. doi:10.1016/0742-8413(91)90095-B


Author Pass M.A.
Mogg T.D.
Title Effect of amitraz and its metabolites on intestinal motility
Journal name Comparative Biochemistry and Physiology. Part C, Comparative   Check publisher's open access policy
ISSN 0306-4492
Publication date 1991-01-01
Sub-type Article (original research)
DOI 10.1016/0742-8413(91)90095-B
Open Access Status Not yet assessed
Volume 99
Issue 1-2
Start page 169
End page 172
Total pages 4
Subject 2403 Immunology
3004 Pharmacology
Abstract 1. Amitraz was rapidly metabolised to BTS27271 after intravenous administration to sheep. 2. Amitraz and BTS27271 had significant H1-histamine antagonist activity on isolated guinea-pig ileum. BTS27271 was approximately 3.3 times as potent as amitraz. 3. Intravenous injection of amitraz and its metabolite BTS27271 caused an immediate cessation of caecal motility in sheep, which persisted for 74-245 min. 4. Caecal stasis induced by amitraz was reversed by yohimbine but only partially reversed by 2-pyridylethylamine. 5. The results suggest that despite the significant antihistamine activity of amitraz and BTS27271 in vitro, it is probably the alpha-2-adrenergic agonist activity that is the most important in causing large intestinal stasis in vivo.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 13 Sep 2016, 11:47:04 EST by System User