Brown L. and Sernia C. (1994) ANGIOTENSIN RECEPTORS IN CARDIOVASCULAR DISEASES. Clinical and Experimental Pharmacology and Physiology, 21 10: 811-818. doi:10.1111/j.1440-1681.1994.tb02450.x

Author Brown L.
Sernia C.
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 1440-1681
Publication date 1994-01-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.1994.tb02450.x
Volume 21
Issue 10
Start page 811
End page 818
Total pages 8
Subject 1314 Physiology
3004 Pharmacology
2737 Physiology (medical)
Abstract 1. Angiotensin II (AII) plays a major role in cardiovascular function via direct actions on the vasculature, kidney, adrenal, heart, brain and sympathetic nerves. The cellular effects of AII are extensive and encompass hypertrophy, hyperplasia and the deposition of extracellular matrix. 2. The actions of AII are mediated by the AT1 and AT2 membrane receptor subtypes, and additional forms of each subtype. Evidence is emerging that selective changes in AII receptor subtypes occur in cardiovascular diseases. 3. Thyroid dysfunction increased cardiac, liver and kidney AII receptor density but decreased adrenal gland receptor density. In the heart, there was a selective increase in AT2 receptor density. 4. Diabetes increased cardiac, liver and adrenal gland AII receptor densities but decreased kidney receptor density. 5. Hypertension increased AII receptor density in the heart and kidney. A corresponding increase in receptor mRNA was prevented by selective AT1 receptor antagonists. 6. The human heart contained AII receptors in all chambers; right atrial receptor density was increased in coronary artery bypass graft patients. 7. The presence of AII receptor changes in these models of cardiac hypertrophy and hypertension raises the possibility of using orally active, subtype‐selective agonists and antagonists to treat particular forms of cardiovascular diseases. Copyright
Keyword angiotensin II (AII) receptors
renin‐angiotensin system
thyroid dysfunction.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 27 times in Scopus Article | Citations
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