Ultrastructural changes induced by actinomycin D in acinar cells in submandibular glands of rats

Adkins K.F. (1974) Ultrastructural changes induced by actinomycin D in acinar cells in submandibular glands of rats. Archives of Oral Biology, 19 10: . doi:10.1016/0003-9969(74)90047-8


Author Adkins K.F.
Title Ultrastructural changes induced by actinomycin D in acinar cells in submandibular glands of rats
Journal name Archives of Oral Biology   Check publisher's open access policy
ISSN 0003-9969
Publication date 1974-01-01
Sub-type Article (original research)
DOI 10.1016/0003-9969(74)90047-8
Volume 19
Issue 10
Total pages 1
Subject 2733 Otorhinolaryngology
3500 Dentistry
1307 Cell Biology
Abstract Actinomycin D is a cytotoxic antibiotic which suppresses RNA and protein synthesis in many cells with consequential changes in the morphology and arrangement of organelles. Its effects on the fine structure of acinar cells in submandibular glands were studied in adult rats which had each received 75 μg of actinomycin D in a single intraperitoneal injection. There were no detectable structural changes in the first 24 hr. Three and 6 days following the injections, the arrangement and shape of the cells and the location and morphology of some cytoplasmic structures and organelles were aberrant. Ballooning degeneration in many mitochondria and development of numerous vesicles, cytolysosomes and myelin figures were prominent features. By the 9th day, there was evidence of early resumption of synthesis and secretion granules were increasing in numbers. Whorled arrangements of endoplasmic reticulum were distinctive in the treated cells.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 13 Sep 2016, 11:24:04 EST by System User