THE EFFECT OF INTRAVENOUS HYPERTONIC SALINE INFUSION ON RENAL FUNCTION AND VASOPRESSIN EXCRETION IN SHEEP

Yesberg N.E., Henderson M. and Budtz-Olsen O.E. (1978) THE EFFECT OF INTRAVENOUS HYPERTONIC SALINE INFUSION ON RENAL FUNCTION AND VASOPRESSIN EXCRETION IN SHEEP. Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 63 4: 331-339. doi:10.1113/expphysiol.1978.sp002446


Author Yesberg N.E.
Henderson M.
Budtz-Olsen O.E.
Title THE EFFECT OF INTRAVENOUS HYPERTONIC SALINE INFUSION ON RENAL FUNCTION AND VASOPRESSIN EXCRETION IN SHEEP
Journal name Quarterly Journal of Experimental Physiology and Cognate Medical Sciences   Check publisher's open access policy
ISSN 1469-445X
Publication date 1978-10-10
Sub-type Article (original research)
DOI 10.1113/expphysiol.1978.sp002446
Open Access Status
Volume 63
Issue 4
Start page 331
End page 339
Total pages 9
Subject 1314 Physiology
Abstract Conscious Merino ewes were given an intravenous hypertonic sodium chloride load of 4 mmol. min−1 for 100 min. This resulted in increases in urine flow, sodium and potassium excretion and plasma sodium concentration and osmolality. Urinary vasopressin output and solute‐free water reabsorption increased and plasma renin activity declined. Renal plasma flow and glomerular filtration rate (GFR) rose, as did the solute clearance. The change in urinary osmolality was related to the initial urine osmolality such that when the initial urine osmolality was high the urine became more dilute, and vice versa. Tubular sodium reabsorption increased but the fractional reabsorption rate fell. It is suggested that the increase in GFR was at least partly due to the increase in AVP and that the electrolyte loss can be accounted for by the increase in GFR without necessarily involving AVP or other hormonal effects at the tubular level.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 13 Sep 2016, 11:22:07 EST by System User