Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta

Dickinson R.G., Fowler D.W. and Kluck R.M. (1989) Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta. Clinical and Experimental Pharmacology and Physiology, 16 10: 789-797. doi:10.1111/j.1440-1681.1989.tb01517.x


Author Dickinson R.G.
Fowler D.W.
Kluck R.M.
Title Maternofetal transfer of phenytoin, p-hydroxy-phenytoin and p-hydroxy-phenytoin-glucuronide in the perfused human placenta
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 0305-1870
Publication date 1989-01-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.1989.tb01517.x
Open Access Status
Volume 16
Issue 10
Start page 789
End page 797
Total pages 9
Language eng
Subject 1314 Physiology
2736 Pharmacology (medical)
3000 Pharmacology, Toxicology and Pharmaceutics
Abstract 1. Transplacental transfer of the anti‐epileptic agent phenytoin (PHT), its phase I metabolite, p‐hydroxy‐phenytoin (p‐OH‐PHT), and its phase II conjugate p‐OH‐PHT‐glucuronide, was studied in term placental lobules perfused single pass in both maternal and fetal circuits. 2. Ratios of clearance of PHT, p‐OH‐PHT and p‐OH‐PHT‐glucuronide to clearance of antipyrine were 1.08 ± 0.03, 0.52 ± 0.02 and 0.12 ± 0.01 (mean and s.e.m.), respectively. 3. Transfer was positively correlated with lipophilicity as measured by the apparent partition coefficient determined between octanol and pH 7.4 buffer. Copyright
Keyword glucuronates
maternal‐fetal exchange
phenytoin
placenta
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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