Mammographic screening trials for women aged under 50. A quality assessment and meta-analysis

Glasziou P.P., Woodward A.J. and Mahon C.M. (1995) Mammographic screening trials for women aged under 50. A quality assessment and meta-analysis. Medical Journal of Australia, 162 12: 625-629.

Author Glasziou P.P.
Woodward A.J.
Mahon C.M.
Title Mammographic screening trials for women aged under 50. A quality assessment and meta-analysis
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
Publication date 1995-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 162
Issue 12
Start page 625
End page 629
Total pages 5
Language eng
Subject 2700 Medicine
Abstract Objective: To carry out a systemic quality review and meta-analysis of all randomised trials of mammographic screening that included women aged under 50 years. Data sources: Reports of randomised trials of mammographic screening were identified via MEDLINE and checks of the bibliographies of retrieved articles and reviews. Data synthesis: Identified trials were assessed for: (i) method of randomisation; (ii) documented comparability of baseline data; (iii) standardised criteria for breast cancer death; (iv) use of an 'intention-to-treat analysis'. Seven randomised trials including almost 160 000 women aged under 50 were studied. The combined estimate of relative risk was 0.95 (95% confidence interval, 0.77-1.18), a statistically non-significant reduction of 5%. Adjustment for the cluster randomisation of two trials, and for degree of compliance, did not substantially change this result. Conclusions: These analyses suggest little, if any, benefit for women under 50 years of age. The results are not explained by the quality of the trials or the radiology. We recommend that women in this age group intending to be screened should be fully informed of these results.
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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Created: Tue, 13 Sep 2016, 11:17:46 EST by System User