Immediate early gene expression during morphine withdrawal

Beckmann A.M., Matsumoto I. and Wilce P.A. (1995) Immediate early gene expression during morphine withdrawal. Neuropharmacology, 34 9: 1183-1189. doi:10.1016/0028-3908(95)00089-O

Author Beckmann A.M.
Matsumoto I.
Wilce P.A.
Title Immediate early gene expression during morphine withdrawal
Journal name Neuropharmacology   Check publisher's open access policy
ISSN 0028-3908
Publication date 1995-01-01
Sub-type Article (original research)
DOI 10.1016/0028-3908(95)00089-O
Volume 34
Issue 9
Start page 1183
End page 1189
Total pages 7
Subject 2804 Cellular and Molecular Neuroscience
3004 Pharmacology
3002 Drug Discovery
Abstract The expression of immediate early genes (IEG)s c-fos, c-jun and zif/268 was studied during naloxone-precipitated morphine withdrawal in various organs of the rat. Dependence was induced over a period of 6 days by a graded regimen of 6-hourly injections. Northern analysis revealed peak expression of all IEGs occurred in the forebrain plus cerebellum at 20 min and at 60 min in the brain stem following morphine withdrawal. Increased levels of c-fos and c-jun mRNA were observed in the spinal cord at 40 min of morphine withdrawal. An increase in c-fos and c-jun but not zif/268 mRNAs was seen in the jejunum between 20 and 60 min. Elevated levels of the IEG protein products in the cerebral cortex, hippocampus, thalamus, cerebellum, brain stem and spinal cord were observed at 60 min following morphine withdrawal. These data emphasize the temporal and spatial variation in IEG expression in different tissues during opiate withdrawal.
Keyword brain
immediate early genes
spinal cord
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: TR Web of Science Citation Count  Cited 44 times in Thomson Reuters Web of Science Article | Citations
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