Multidrug-resistant organisms in liver transplant: mitigating risk and managing infections

Hand, Jonathan and Patel, Gopi (2016) Multidrug-resistant organisms in liver transplant: mitigating risk and managing infections. Liver Transplantation, 22 8: 1143-1153. doi:10.1002/lt.24486

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Author Hand, Jonathan
Patel, Gopi
Title Multidrug-resistant organisms in liver transplant: mitigating risk and managing infections
Journal name Liver Transplantation   Check publisher's open access policy
ISSN 1527-6473
1527-6465
Publication date 2016-08-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/lt.24486
Open Access Status File (Author Post-print)
Volume 22
Issue 8
Start page 1143
End page 1153
Total pages 11
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Liver transplant (LT) recipients are vulnerable to infections with multidrug-resistant (MDR) pathogens. Risk factors for colonization and infection with resistant bacteria are ubiquitous and unavoidable in transplantation. During the past decade, progress in transplantation and infection prevention has contributed to the decreased incidence of infections with methicillin-resistant Staphylococcus aureus. However, even in the face of potentially effective antibiotics, vancomycin-resistant enterococci continue to plague LT. Gram-negative bacilli prove to be more problematic and are responsible for high rates of both morbidity and mortality. Despite the licensure of novel antibiotics, there is no universal agent available to safely and effectively treat infections with MDR gram-negative organisms. Currently, efforts dedicated toward prevention and treatment require involvement of multiple disciplines including transplant providers, specialists in infectious diseases and infection prevention, and researchers dedicated to the development of rapid diagnostics and safe and effective antibiotics with novel mechanisms of action. Liver Transplantation 22 1143-1153 2016 AASLD.
Formatted abstract
Liver transplant (LT) recipients are vulnerable to infections with multidrug-resistant (MDR) pathogens. Risk factors forcolonization and infection with resistant bacteria are ubiquitous and unavoidable in transplantation. During the pastdecade, progress in transplantation and infection prevention has contributed to the decreased incidence of infections withmethicillin-resistant Staphylococcus aureus. However, even in the face of potentially effective antibiotics, vancomycin-resistant enterococci continue to plague LT. Gram-negative bacilli prove to be more problematic and are responsible forhigh rates of both morbidity and mortality. Despite the licensure of novel antibiotics, there is no universal agent availableto safely and effectively treat infections with MDR gram-neg ative organisms. Currently, efforts dedicated towardprevention and treatment require involvement of multiple dis ciplines including transplant prov iders, specialis ts in infec-tious dis eases and infect ion prev ention, an d rese archers de dicated to the development of rapid diagnostics and safe andeffective antibioti cs with novel m echanisms of action.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
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