Nomenclature of homodetic cyclic peptides produced from ribosomal precursors: an IUPAC Task Group interim report

Craik, David J., Youn Young Shim, Goransson, Ulf, Moss, Gerard P., Tan, Ninghua, Jadhav, Pramodkumar D., Shen, Jianheng and Reaney, Martin J. T. (2016) Nomenclature of homodetic cyclic peptides produced from ribosomal precursors: an IUPAC Task Group interim report. Biopolymers, 106 6: 917-924. doi:10.1002/bip.22939


Author Craik, David J.
Youn Young Shim
Goransson, Ulf
Moss, Gerard P.
Tan, Ninghua
Jadhav, Pramodkumar D.
Shen, Jianheng
Reaney, Martin J. T.
Title Nomenclature of homodetic cyclic peptides produced from ribosomal precursors: an IUPAC Task Group interim report
Journal name Biopolymers   Check publisher's open access policy
ISSN 1097-0282
Publication date 2016-08-23
Sub-type Article (original research)
DOI 10.1002/bip.22939
Open Access Status Not yet assessed
Volume 106
Issue 6
Start page 917
End page 924
Total pages 36
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract In 2015, an International Union of Pure and Applied Chemistry (IUPAC) Task Group was formed to develop nomenclature recommendations for homodetic cyclic peptides produced from ribosomal precursors. Delegates of the 2015 International Conference on Circular Proteins (ICCP) were presented with the strengths and weaknesses of four published approaches to homodetic cyclic peptide nomenclature, and a summary of the ensuing discussion is presented here. This interim report presents a potentially novel suggestion – the use of Cahn-Ingold-Prelog rules to specify amino acid priority in homodetic peptides for consistent numbering. Indeed, this might be the first extension of the Cahn-Ingold-Prelog rules in five decades. The authors invite interested parties to contact the corresponding author with suggestions for the improvement of the proposed nomenclature; these ideas will be discussed and considered for inclusion in the final report.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Accepted Manuscript. Published online 23 August 2016

Document type: Journal Article
Sub-type: Article (original research)
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Created: Fri, 09 Sep 2016, 22:08:21 EST by Susan Allen on behalf of Institute for Molecular Bioscience