Roseopurpurins: chemical diversity enhanced by convergent biosynthesis and forward and reverse Michael additions

Shang, Zhuo, Khalil, Zeinab, Li, Li, Salim, Angela A., Quezada, Michelle, Kalansuriya, Pabasara and Capon, Robert J. (2016) Roseopurpurins: chemical diversity enhanced by convergent biosynthesis and forward and reverse Michael additions. Organic Letters, 18 17: 4340-4343. doi:10.1021/acs.orglett.6b02099


Author Shang, Zhuo
Khalil, Zeinab
Li, Li
Salim, Angela A.
Quezada, Michelle
Kalansuriya, Pabasara
Capon, Robert J.
Title Roseopurpurins: chemical diversity enhanced by convergent biosynthesis and forward and reverse Michael additions
Journal name Organic Letters   Check publisher's open access policy
ISSN 1523-7060
1523-7052
Publication date 2016-09-02
Year available 2016
Sub-type Article (original research)
DOI 10.1021/acs.orglett.6b02099
Open Access Status Not yet assessed
Volume 18
Issue 17
Start page 4340
End page 4343
Total pages 4
Place of publication Washington, DC United States
Publisher American Chemical Society
Language eng
Formatted abstract
Cultures of the estuarine fungus Penicillium roseopurpureum (CMB-MF038) yielded a diverse array of polyketides, many of which were related via a highly convergent biosynthetic pathway. In addition to revising and assigning structures, and documenting chemical and biological properties, pro-drug cytotoxic properties were attributed to roseopurpurins H (10) and I (11) on the basis of in situ reverse Michael addition to a cytotoxic Michael acceptor (12).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 09 Sep 2016, 21:55:10 EST by Susan Allen on behalf of Institute for Molecular Bioscience