Old dogs and new tricks in antimicrobial discovery

Butler, Mark, Blaskovich, Mark, Owen, Jeremy G. and Cooper, Matthew (2016) Old dogs and new tricks in antimicrobial discovery. Current Opinion in Microbiology, 33 25-34. doi:10.1016/j.mib.2016.05.011


Author Butler, Mark
Blaskovich, Mark
Owen, Jeremy G.
Cooper, Matthew
Title Old dogs and new tricks in antimicrobial discovery
Journal name Current Opinion in Microbiology   Check publisher's open access policy
ISSN 1369-5274
1879-0364
Publication date 2016-10-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.mib.2016.05.011
Open Access Status Not yet assessed
Volume 33
Start page 25
End page 34
Total pages 10
Place of publication Oxford United Kingdom
Publisher Elsevier
Language eng
Subject 2404 Microbiology
2726 Microbiology (medical)
2725 Infectious Diseases
Abstract The discovery of new antibiotics is crucial if we are to avoid a future in which simple infections once again lead to death. New antibiotics were traditionally discovered by analyzing extracts from cultured soil-derived microbes. However, in the last few years only a few new antibiotic classes have been identified using this method. Attempts to apply target-based screening approaches to antibiotic discovery have also proven to be unproductive. In this article, we describe how DNA sequencing and bioinformatic techniques are revolutionizing natural product discovery leading to new natural product antibiotics sourced from both cultivated and uncultivated microbes. New chemical structures are also being ‘crowd sourced’ from chemists around the world, and ‘forgotten’ antibiotics repositioned for clinical trials after chemical or biochemical modification of the original natural product. Collectively such approaches have the potential to revamp antibiotic lead discovery and re-invigorate the antibiotic pipeline.
Keyword Microbiology
Microbiology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID APP1059354
WT141107
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Fri, 09 Sep 2016, 01:07:58 EST by Susan Allen on behalf of Institute for Molecular Bioscience