Effect of Long‐term Corticosteroid Therapy on Monocyte Chemotaxis in Man

TANNER A.R., HALLIDAY J.W. and POWELL L.W. (1980) Effect of Long‐term Corticosteroid Therapy on Monocyte Chemotaxis in Man. Scandinavian Journal of Immunology, 11 3: 335-340. doi:10.1111/j.1365-3083.1980.tb00242.x


Author TANNER A.R.
HALLIDAY J.W.
POWELL L.W.
Title Effect of Long‐term Corticosteroid Therapy on Monocyte Chemotaxis in Man
Journal name Scandinavian Journal of Immunology   Check publisher's open access policy
ISSN 1365-3083
Publication date 1980-01-01
Sub-type Article (original research)
DOI 10.1111/j.1365-3083.1980.tb00242.x
Volume 11
Issue 3
Start page 335
End page 340
Total pages 6
Subject 2403 Immunology
2700 Medicine
Abstract The influence of prednisolone on monocyte chemotactic activity in vitro at prednisolone concentrations comparable with those achieved in man following oral dosage has been investigated. Chemptactic activity of monocytes from each of sixteen normal subjects was suppressed by concentrations of prednisolone as low as 25 ng/ml (suppression of chemotaxis, 20%). Maximal suppression occurred at 100 ng/ml (suppression of chemotaxis, 48%) and no significant increase in suppression was produced by increasing the concentration to 200 ng/ml (suppression of chemotaxis, 53%). In contrast, monocytes isolated from ten patients receiving corticosteroid therapy showed no significant suppression of chemotactic activity when exposed to these concentrations of prednisolone, even though they exhibited a normal ability to respond to a chemotactic stimulus. The lack of suppression of monocyte chemotaxis in patients receiving corticosteroid therapy is unexplained, but may represent a change in the circulating monocyte or lymphocyte populations. Copyright
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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