Analysis of Duboisia myoporoides R.Br. and Duboisia leichhardtii F. Muell.

Griffin W.J., Brand H.P. and Dare J.G. (1975) Analysis of Duboisia myoporoides R.Br. and Duboisia leichhardtii F. Muell.. Journal of Pharmaceutical Sciences, 64 11: 1821-1825. doi:10.1002/jps.2600641115

Author Griffin W.J.
Brand H.P.
Dare J.G.
Title Analysis of Duboisia myoporoides R.Br. and Duboisia leichhardtii F. Muell.
Journal name Journal of Pharmaceutical Sciences   Check publisher's open access policy
ISSN 0022-3549
Publication date 1975-01-01
Sub-type Article (original research)
DOI 10.1002/jps.2600641115
Open Access Status Not yet assessed
Volume 64
Issue 11
Start page 1821
End page 1825
Total pages 5
Language eng
Subject 1313 Molecular Medicine
1600 Chemistry
1605 Policy and Administration
3002 Drug Discovery
3003 Pharmaceutical Science
3004 Pharmacology
Abstract Duboisia were analyzed for scopolamine and hyoscyamine using GLC, by a slope ratio method, and by methods employing homatropine, tetraphenylethylene, and phenylacetyltropine as internal standards. Limits of precision were determined by the inverse prediction method. Phenylacetyltropine was the preferred internal standard. The alkaloids were silanized with either hexamethyldisilazane or N,O‐bis(trimethylsilyl)acetamide to prevent dehydration to the apo forms. Samples from a commercial bale of Duboisia myoporoides were assayed. The alkaloid content varied considerably, depending on the sample position within the bale. Copyright
Keyword Duboisia myoporoides and Duboisia leichhardtii—GLC analysis for scopolamine and hyoscyamine, slope ratio method
Phenylacetyltropine—internal standard in GLC analysis of scopolamine and hyoscyamine in Duboisia samples
Scopolamine and hyoscyamine—GLC determination in Duboisia samples, slope ratio method
Q-Index Code C1
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
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Citation counts: Scopus Citation Count Cited 19 times in Scopus Article | Citations
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Created: Tue, 06 Sep 2016, 11:44:51 EST by System User